| Club Name | Staff Representative | Location | Meeting dates |
| Art Club | Ms. Bartlett, Ms. Milkovic, Ms. Morgante, Ms. Scuilli | Room 111&112 | Wednesdays |
| AV / Sound & Light Crew | Mr. Justin Ieraci | | As needed |
| Best Buddies | Ms. Amato and Ms. Warren | Room 223 | Tuesdays |
| Board Game Club | Mr. Postma | Cafeteria | Mondays after school |
| Book Club | Mr. Hodges | Library | Wednesdays after school |
| Breakfast Club | Ms. Marcijus, Mr. Bastian | Atrium | Mon – Fri 7:50 – 8:10 |
| Breaking Barriers GSA | Ms. Bartlett | Room 111 | Tuesdays |
| BSU | Ms. Currie | Room 115 | Wednesdays after school |
| Culture Club | Ms. Linay | Port 11 | Every other Tuesday |
| DECA Business Club | Mr. Crisostimo and Ms. Sabo Mann | Room 210 | Wednesdays |
| Drama Club | Ms. Boere & Ms. D’Amico | Theatre & Drama Room | Mondays and Thursdays |
| Dungeons & Dragons club | Ms. Evans, Ms. Broadley, Ms. Gremmen | Room 220 | Fridays |
| HOSA | Ms. Nixon | Room 311 | will be posted |
| Knights for Safe Spaces | Ms. McGillivray and Ms. Porciello | TBD | 1 Tuesday per month |
| Latin American Club | Mr. Lira | Port 23 | TBD |
| Legion of Geeks | Ms. Evans, Ms. Broadley, Ms. Gremmen | Room 220 | Alternate Wednesdays |
| Math Contest Club | Ms. Turchet | Room 307 | Tuesdays (TBD) |
| Math Help | Ms. Turchet | Room 303, room 304 | Mondays after school |
| Mentorship | Ms. DiGiuseppe, Ms. Rattray, Ms. Wiencis, Ms. Hihn, Mr. DeRubies, Mr. Fuciarelli | Library | 2 Mondays / month |
| Mock Trail Team | Ms. Campanelli and Mr. Livingston | Room 204/207 | As needed |
| Model UN Club | Ms. Campanelli | Library | Every 2nd & 3rd Tue |
| Morning Workout Club | Mr. Del Gobbo | Weight room | Mornings |
| Muslim Student Association | Ms. Bell | Room 116 | Tuesdays |
| Physics Help | Ms. Fleming | Room 321 | Wednesdays after school |
| Robotics Club | Mr. Peters | Room 313 | TBD |
| St. FX Choir | Ms. Caruana | Music Room – 108 | Wednesdays after school |
| St. FX Jazz Band | Ms. Caruana | Music Room – 108 | Tuesdays after school |
| St. FX Junior Band | Ms. Caruana | Music Room – 108 | Mondays after school |
| St. FX Reps | Ms. Cholewka, Ms. Fraser, Ms. Talbot | Room 222 | Wednesdays after school |
| St. FX Senior Concert Band | Ms. Caruana | Music Room – 108 | Thursday 2:20 – 3:45/4:00 |
| STEAM Club | ILAO/CHAN/LUKEY/GUERIN | MakerSpace | Every Monday After School 2:30 – 3:30PM |
| Trivia Club | Michael Fuciarelli | Room 208 | Thursdays |
| Xavier Times – School Newspaper Club | Mr. Crisostimo, Mr. Hodges | Room 210, library | Every other Thursday – twice a month |
